Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption. Most lipids are made in a cell organelle called the ...

Interest in lipid nanoparticles (LNPs) as delivery vehicles for precision therapies in genetic diseases and cancers remains at an all-time high. Now, scientists from the University of Pennsylvania, ...

Dried mRNA vaccines can match standard injection without cold storage when a polymer matrix at the right ratio prevents the ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

“We’ve never had such an in-depth map of the CD1 lipidome available,” said Patricia Barral, an immunologist at King’s College London who was not involved with the work. “It will enable us to start ...

Researchers have used artificial intelligence to design ionizable lipids that outperform current gold-standard molecules in delivering mRNA, a key technology in vaccines and gene therapies. The ...

The bottom of the ocean is not hospitable: there is no light, the temperature is freezing cold, and the pressure of all the water above will literally crush you. The animals that live at this depth ...

Lipid nanoparticles (LNPs) are one of the most exciting technologies in drug delivery. LNPs protect and deliver genetic material into cells, allowing a large spectrum of RNA therapeutics, including ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise. Those symptoms, which typically resolve within days, are the natural ...

Share on Pinterest Our lipid profile may hold vital clues about our health. Image credit: Yamada Taro/Getty Images. Lipids are fatty compounds that are one of the building blocks needed to make living ...