The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

The San Francisco 49ers outlasted the Indianapolis Colts 48-27 on the road to close out Week 16 on Monday Night Football, ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 ...

Cars with human drivers were forced to try to navigate between the vehicles after the widespread power outage left the Bay ...

As San Francisco 49ers legend Steve Young has watched Colts quarterback Philip Rivers come out of retirement at 44, the Pro ...

Waymos stopped in the middle of intersections during a mass power outage in San Francisco over the weekend, causing the robotaxi company to suspend service for a day.

Barry Manilow has postponed his January concerts, including an Orlando stop at the Kia Center, after the discovery of a cancerous spot on his left lung.

The Chicago Transit Authority extended the No. 93 California/Dodge bus route to the Logan Square Blue Line subway station.

An outage hit San Francisco, crippling transit and forcing Waymo to halt self-driving taxis as cars stalled at intersections.

About 21,000 PG&E customers in San Francisco remained without electricity as of 7:30 a.m. Sunday, after about 130,000 lost ...