The San Francisco Giants and Houston Astros play on Wednesday with the winner claiming the three-game series.

The Arizona Diamondbacks and Colorado Rockies meet on Wednesday with the winner claiming the three-game series.

Both the Minnesota Twins and the Baltimore Orioles are looking for a series win with a victory on Wednesday.

The St. Louis Cardinals and Philadelphia Phillies meet on Wednesday with the winner claiming the three-game series.

The San Francisco Giants will try to end a three-game losing streak when they play the Houston Astros.